Description

Position Overview 

We are seeking an experienced and hands-on Principal Scientist in ADME/PK to lead and contribute to pharmacokinetics, biodistribution, and translational modeling efforts for a next-generation tumor targeting technology based on a click chemistry enabled pre-targeting. 

You will work at the interface of chemistry, biology, and translational sciences to design and interpret studies that contribute to therapeutic design, candidate selection, IND-enablement, and clinical strategy in a fast-paced startup environment. 

Key Responsibilities 

Strategy & Leadership 

• Define and execute ADME/PK strategies for pre-targeted therapeutics, including antigen-targeting modalities, clickable prodrugs (protodrugs), and active payloads
• Lead PK/PD and biodistribution strategy to support platform validation and pipeline programs
• Partner cross-functionally with chemistry, protein engineering, and biology teams to optimize delivery efficiency and exposure
• Serve as the subject matter expert on PK for pre-targeting systems and click chemistry-enabled therapeutics 

Preclinical Development

• Design and interpret PK, biodistribution, and mass balance studies across components of the technology to therapeutic design, validation, and development
• Collaborate with Bioanalytical assay development team to support assay development 

Modeling & Translation

• Build and apply PK/PD and mechanistic models to predict human dosing and scheduling
• Translate preclinical data into clinical hypotheses and first-in-human strategies 

Collaboration & Communication

• Work closely with CMC and analytical teams to ensure bioanalytical readiness
• Partner with toxicology and regulatory teams to support IND-enabling studies
• Present data and strategy to leadership, investors, and external collaborators 

Requirements

Required Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Bioengineering, or related field
• 4+ years of industry experience in ADME/PK (biotech/pharma), including ADME/PK leadership on therapeutic programs
• Deep expertise in PK of biologics and/or targeted delivery systems (e.g., ADCs, radioconjugates, bispecifics)
• Strong experience designing and interpreting in vivo PK and biodistribution studies
• Demonstrated experience with PK/PD modeling tools (e.g., Phoenix WinNonlin, NONMEM, Monolix, MATLAB, or similar) 

Preferred Qualifications

• Experience with pre-targeting approaches, multi-component therapeutics, or bioorthogonal chemistry systems
• Familiarity with click chemistry reactions (e.g., tetrazine–TCO) in biological systems
• Background in oncology, targeted therapeutics, or drug delivery platforms
• Experience with imaging-based biodistribution (e.g., PET/SPECT, fluorescence)
• Knowledge of regulatory expectations for PK/ADME in IND filings
• Strong publication record and presentation skills 

Desired Attributes (Startup Mindset)

• Excellent colleague and collaborator
• Thrive in a fast-moving drug development environment
• Scientific curiosity and willingness to operate in uncharted territory
• Be comfortable working with ambiguity and solving complex problems
• Strong cross-disciplinary communication skills
• Hands-on, roll-up-your-sleeves mindset
• Passion for improving the lives of cancer patients